Summary:
Two-thirds of all women who develop breast cancer each
year live in Asia. In many countries, including Bangladesh,
there are few data on the pathological characteristics of
breast tumours. The objectives of this study were a) to
describe the estrogen receptor (ER), progesterone receptor
(PR), and the expression of Her-2/neu oncogene expression
status in a large series of breast cancers occurring in
Bangladeshi women and b) to correlate these findings with
the patients’ age at diagnosis, tumour histological grade,
and presence of axillary lymph node metastatic disease.
Method: One thousand forty two cases were evaluated in a
referral practice. Tumour sections were stained
immunohistochemically using Dako 1D5 (ER) and Dako
636 (PR) and semiquantitatively scored for ER and PR
expression. Three hundred thirty five of these cases were
also stained using Dako c-erb2 oncoprotein and scored for
Her-2/neu over-expression.