Summary:
An open controlled chemotherapeutic trial to describe the
efficacy of mefloquine in an area with reported
mefloquine resistance in a multi-drug resistant
falciparum area of Bangladesh was done. Subjects were
symptomatic patients, 12 years or older, with parasite
density between 500-250,000/cmm and no history of
taking antimalarials during the previous week. The
regimens used were mefloquine 25 mg/Kg, divided into
two doses six hours apart in 70 cases, and oral quinine
sulphate tablets (10 mg/Kg eight hourly) for seven days in
seven cases. Five healthy controls were recruited. Subjects
were kept in a reasonably reinfection free environment in
a makeshift hospital for 28 days. Drug administration was
supervised and subjects were followed up clinically and