Summary:
Fatty liver is a common cause of chronic liver disease in
developed as well as developing countries.We have designed
this study to estimate the prevalence and predictors for non
alcoholic steatohepatitis (NASH) in non alcoholic fatty liver
disease (NAFLD). We have included 493 patients with
sonographic evidence of fatty change in liver and 177 of
them had done liver biopsy for histopathological study.
Other causes of liver disease and alcohol consumption were
excluded. Metabolic syndrome and biochemical and
anthropometric evaluation was done. Females were
predominating 250 (57.0 %). Centrally obese 422 (96.2 %)
was more than over all obesity330 (75.1%). NASH was
absent in 10 (5.6%) cases and diagnostic of NASH was 75
Journal of Bangladesh College of Physicians and Surgeons
Vol. 32, No. 2, April 2014
(42.4 %).Presence of diabetes could significantly (p = 0.001)
predicted NASH. Age, sex, BMI, waist circumference,
Serum HDL,triglyceride, insulin resistance index,
hypertension, metabolic syndrome could not predict NASH.
Serum GGT level was significantly (p = 0.05) higher in
NASHwith a sensitivity of 45 % and specificity of 68 % only.
Serum ALT and AST level could not detect NASH. Females
were predominant sufferer of NAFLD in Bangladesh.
Prevalence of NASH was much higher42.4%. Diabetes was
the main predictor of NASH. GGT was the only biochemical
indicator of NASH. We recommend liver biopsy in NAFLD
with diabetes and raised GGT.
(J Banagladesh Coll Phys Surg 2014; 32: 71-77)