Summary:
The chance of two chromosome abnormalities occurring
in one conceptus is rare. Here we report two cases of double
aneuploidy with karyotype 48,XYY,+21 and 48,XXY,+21.The
diagnosis was confirmed by cytogenetic analysis using
peripheral blood followed by Giemsa banding technique.
Clinically both the children had most of the phenotypic
features of Trisomy 21. However phenotypic features of XYY
were not present but the child with XXY had undescended
right testis .The purpose of this communication is to report
such rare disorders discovered as the result of the evaluation
for Trisomy 21.
Key words: Cytogenetics, double aneuploidy, Trisomy 21,
sex chromosomes.