Summary:
Acute kidney injury (AKI) usually detected by s. creatinine,
which rises after 48 hrs of insult causes delay in diagnosis
and to take preventive or therapeutic measures. Hence amongst
many neutrophil gelatinase associated lipocalin (NGAL) is
emerging as early, sensitive, and most promising biomarker
of AKI both in urine and plasma.
This prospective cross sectional observational study was
carried out in Combined Military Hospital (CMH) Dhaka
from October 2011 to March 2012. A total of willing 100
adult patients undergoing elective coronary angiogram
(CAG) with normal kidney function were included in this
study. Our study defined contrast induced AKI (CI-AKI) as
rise of serum creatinine by >25% or e”0.5 mg/dl from
baseline after exposure to contrast media and urine NGAL
e”100 ng/ml was taken as cut off value to predict AKI as
calculated by ROC curve. The main outcome measures were
urine NGAL at 4 hrs and serum creatinine at 48 hrs after
CAG. Significant elevation of urine NGAL was noted in 9
patients after 4 hrs of CAG, of them 8 (8%) patients developed
raised s. creatinine (AKI) after 48 hrs. Patient demographics
and procedural factors were although statistically significant
in few instances but none was predictive of AKI.
Keywords: NGAL, Biomarker, CI-AKI, Cardiac catheterization.
(J Banagladesh Coll Phys Surg 2015; 33: 133-139)