Summary:
Sepsis is a systemic, deleterious host response to infection
leading to acute organ dysfunction secondary to documented
or suspected infection and septic shock i.e. sepsis plus
hypotension not reversed with fluid resuscitation. Severe sepsis
is a major healthcare problem with an extremely high
mortality rate of 30-60% and it is one of the most common
reasons for critically ill patients to be admitted to an intensive
care unit (ICU). Excessive inflammation and coagulation
and suppression of fibrinolysis are the hallmarks of Sepsis.
Our medical concern is to manage sepsis and to prevent
multi organ failure (MOF). Making an early, accurate
diagnosis of septic shock is the key to increasing survival
rates. With no specific, effective anti-sepsis therapies
available, management focuses on haemodynamic
stabilization and rapid resuscitation, early source control,
adequate and appropriate antibiotics, organ support and
modulation of the septic responses are the cornerstones of
treatment.
Key Words: Sepsis, severe sepsis, Septic shock.
(J Bangladesh Coll Phys Surg 2016; 34: 206-212)