Summary:
Objective: Acne vulgaris is the disease of the teenagers as
90% of them being affected. So many treatment modalities
are there - systemic , topical and physical . Among them
topical therapy is the main stay of treatment.
Our study was to determine the efficacy and safety of
combination of erythromycin/benzyl peroxide compared
with benzyl peroxide alone in the treatment of mild to
moderate acne.
Method: Patients attended in a Charity Foundation were
enrolled for the study after fulfilling the criteria. Among
total 50 patients 25 were selected for group A and another
25 for group B..
Group A were treated with 3% erythromycin and 5% Benzyl
peroxide combination and GroupB with 5% Benzyl peroxide
only. Total acne lesions were counted at base line and after
4 , 8 and 12 weeks of follow up. Reduction of total no of
lesions were seen and analyzed.
Result: At baseline mean of total acne score was 33.60 ±
5.98 and 33.53 ± 5.68 in group A and B (p=0.965). After 12
week it was 2.27 ± 1.08 and 6.27 ± 1.57 respectively in group
A and B (p=0.001). Percent reduction of acne severity from
base line to final follow up was 93.24 ± 3.11 in group A and
81.17 ± 4.22 in group B (p=0.001). So we can see better
reduction of lesion count in Group A than Group B.
Conclusion: We conclude that Group A is safer and more
effective than that of Group B. So the combination of Benzyl
peroxide and erythromycin is better than Benzyl peroxide
alone.
Key word: Acne , Benzyl peroxide , Erythromycin.
(J Bangladesh Coll Phys Surg 2017; 35: 174-178)