Summary:
Intracerebral haemorrhage is one of the uncommon initial
CNS manifestations of choriocarcinoma in reproductive age
group women. Disease is usually diagnosed by history,
clinical examinations and investigations like CT scan of
brain and chest, MRI of brain, USG, X-ray chest P/A view
and high level of â-hCG in serum and CSF. Overall
prognosis of this disease is generally good (80-90% long
term survival with chemotherapy and radiotherapy). But
intracranial metastasis has poor prognosis which comprises
3-28% of choriocarcinoma. Most intracranial metastasis
occurs late in the course of disease but 20% experiences as
first sign. Our patient is a teenager girl presented with
convulsion and loss of consciousness. CT scan of brain
revealed hemorrhage in right fronto-parietal region with
ventricular extension, X-ray chest P/A view shows metastasis
in mid zone of right lung, USG shows invasion in posterior
myometrium and high concentration of serum â-hCG
(273400 mUI/ ml) confirmed our diagnosis. This case
report describes that the conservative treatment with
radiotherapy and chemotherapy gives good outcome of with
metastasic intracerebral haemorrhage with
choriocarcinoma is rewarding with farther radio and
chemotherapy.
Key word: Choriocarcinoma, metastasis, invasion, Beta
human chorionic gonadotropin (â-hCG).
(J Bangladesh Coll Phys Surg 2019; 37: 151-155)
DOI: https://doi.org/10.3329/jbcps.v37i3.41737