Introduction: Lymphoma is a heterogeneous group of
hematological malignancy that varies in different subtypes
according to geography, age, race and ethnicity. In this
study, the different subtype of lymphoma according to WHO
lymphoid tumor classification and clinical features of Non
Hodgkins lymphoma will be analyzed and discussed at a
tertiary care Hematology center.
Objectives: Our aims and objective is to observe and share
the single center experience of specifically Non-Hodgkin
lymphoma and to contribute in formation of national
lymphoma registry in future to enhance the care of potentially
curable lymphomas.
Materials and Method: A retrospective analysis of 226
diagnosed lymphoma cases were conducted at DMCH
Hematology center from January 2016 to September 2017(
total 21 months period). Data were reviewed and analyzed
using simple frequency and percentage. Protocol was
approved by institutional ethical review board (IRB) of
DMCH.
Result: The mean age of NHL is 43 ( 12-90) years with
majority of patients were in 31-55 years age group and M:F
is 3:1. The mean age of HL is 30 (range 4-60) years without
bimodal peak observed. Mixed cellularity classical HL were
found higher than nodular sclerosis HL.
Majority of NHL were B cell NHL ( 86.25%) and remaining
were T cell NHL (13.75%).
The most common variant found was aggressive diffuse large
B cell lymphoma(DLBCL) (48%), followed by peripheral T
cell lymphoma PTCL (~13%) and very aggressive
lymphoblastic lymphoma (LBL) (11%), low grade follicular
Lymphoma (11%) and others ( ~17%).
70% NHL had nodal presentation and 30% had extra nodal
involvement with GIT and CNS most commonly involved.
Extra nodal presentations were more observed in DLBCL
and LBL. Majority (75%) of NHL presented at advanced
stage with B symptoms observed in 86% and variable IPI
score. In DLBCL cell of origin was detected as non-GCB in
25(41%), GCB in 04( 6%) and unclassifiable in 03(5%)
cases according to Han’s algorithm, and cell of origin was
not detected in remaining cases.
Conclusion: This is a small scale retrospective study, this
can lead raising awareness of doing large scale national
data registry for various lymphoma patients. The thorough
clinical and diagnostic information about lymphoma is
necessary for better management and outcome.
Key words: HL, NHL, PTCL, DLBCL, GCB, non GCB, LBL.
(J Bangladesh Coll Phys Surg 2020; 38: 23-28)
DOI: http://dx.doi.org/10.3329/jbcps.v38i1.44685