TTP (Thrombotic Thrombocytopenic purpura) is a nonimmune,
microangiopathic hemolytic anemia (MAHA),
associated with thrombocytopenia, fever, neurologic or renal
dysfunction. Mixed connective tissue disease (MCTD) is not
a specific disorder and identified serologically by high titers
of of antibodies to RNP. Coexistence of TTP with
asymptomatic MCTD is rare encounter. We describe here a
rare case of secondary TTP in a 42 year, old female presenting
as menorrhagia for seven days, severe headache and one
episode of seizure. This case emphasizes the early diagnosis
of TTP and its association with underlying condition for
proper management and to avoid fatal outcome.
KeyWords: Microangiopathic hemolytic anemia (MAHA);
Thrombotic Thrombocytopenic purpura( TTP); hemolytic
uremic syndrome(HUS); Mixed connective tissue
disease(MCTD); U1-Ribonucleoprotein (RNP); Antineuclear
antibody(ANA); A disintegrin and
metalloproteinase with a thrombospondin type 1 motif,member
13(ADAMTS 13)
(J Bangladesh Coll Phys Surg 2020; 38: 46-48)
DOI: http://dx.doi.org/10.3329/jbcps.v38i1.44688