Abstract:
Introduction: The whole world is on the brink of collapse
due to the outbreak of COVID-19 with no solution to treat
these cases with any specific drug. Extensive search for the
Vaccine or effective treatment is going on while alarming
infection and death toll is rising every day.
Aim: The study will compare the effect of Ivermectin with
Doxycycline and Hydoxychloroquine with Azythromicin on
a selective group of COVID -19 positive patients.
Method: This is a comparative study that included 400
patients of COVID 19 positive patient who were divided in to
two groups. Group- A Received Ivermectin with Doxycycline
and the other group- B received hydroxichloroquine(HCQ)
with azithromycin.
Result: Viral clearance is 132 ( 66%) on day 5 and 167(
83.5% ) on day 6. Among them 33(16.5%) remain PCR
positive after 6th day of Ivermectin ingestion in Group A.
Whereas there is154 ( 77.0%) viral clearance at 11th day and
163(81.5%) viral clearance at 12th day of Hydroxychloroquine
ingestion in Group B. Among them 37 (18.5%)
remain PCR positive after 12 day in group B. The P value is
0.000427 which is significant considering 5th day viral
clearance of Ivermectin ingestion and 11th day of
Hydroxychloroquine ingestion. But considering 6th day and
12th day the P-value is 0.59 which is not significant.
Conclusion: It appears Ivermectin and Doxycycline is
safeand effective combination drug therapy in COVID-
19infected patients but need further extensive study to find
out the scope of application on other groups of patients.
Keywords: COVID-19, Ivermectin, Hydroxychloroquine,
Doxycycline, Doxycycline Azithromycin Hydroxychloroquine
with Azithromycin
(J Bangladesh Coll Phys Surg 2020; 38: 5-9)
DOI: https://doi.org/10.3329/jbcps.v38i0. 47514