Abstract:
Background: The number of COVID-19 patients is
exponentially increasing worldwide since December, 2019.
Management in intensive care units (ICU) has become a
major challenge; therefore, time demanding laboratory
markers for early recognition of morbid forms is utmost
important for timely triaging of patients.
Objective: The present study aimed to evaluate the role of
haemotological and Coagulation profile in the assessment
of disease severity of COVID-19.
Methods: The current study is an observational study done
prospectively in Armed Forces Institute of Pathology (AFIP)
during the period of 28 March 2020 to 15 May 2020. The
study subjects were haematological and coagulation profile
data of 100 COVID-19 patients grouped in non-ICU and
ICU at the baseline and at 4th day of admission in Combined
Military Hospital (CMH), Dhaka. All the data were recorded
and analyzed by SPSS 20.0 programme.
Results: Here subjects with featured of lymphopenia were
detected prominently in our COVID-19 ICU patients with a
median nadir ALC of 0.9 x109/L. The most common pattern
of coagulopathy observed in patients hospitalized with
COVID-19 is characterized by elevation in fibrinogen and Ddimer
levels, particularly significantly higher in ICU group.
Conclusion: The present study is a reflection of significant
anomalies in haematological and coagulation parameters
during the disease process with COVID-19.
Key words: ALC-Absolute lymphocyte count, ANC- Absolute
neutrophil count, Coronavirus, COVID-19, D-dimer, SARSCOV-
2.
(J Bangladesh Coll Phys Surg 2020; 38: 61-66)
DOI: https://doi.org/10.3329/jbcps.v38i0.47347