Abstract:
Polycystic ovary syndrome (PCOS) is the most
common and treatable endocrine dysfunction in
fertile women. The pathophysiology of PCOS
involves primary defects in the
hypothalamic–pituitary axis, insulin secretion and
action, and ovarian function.Studies show 20-40
percent of female first-degree relatives of women
with PCOS also have the syndrome.Genetic studies
have identified a link between PCOS and disordered
insulin metabolism and hyperinsulinemia.PCOS is
characterized by hyperandrogenism, irregular
ovulatory cycle and metabolic derangement,
including glucose intolerance and
hyperinsulinemia. Hyperandrogenism is a clinical
hallmark of PCOS.In women with PCOS,
Ovulation problems are usually the primary cause