Abstract: Background: Surgical site infection (SSI) can affect the surgical procedures in the peripheral hospital adversely and adequate data can help in the management of this unwanted complication. Aim & Objective: The study was conducted with the aim to identify the outcome of surgical site infection (SSI) in a secondary level district hospital. Materials & Methods: A total of 192 patients, underwent general surgical procedures in the 100-bedded district hospital, Shariatpur, Bangladesh from January to December, 2016. All were observed for development of SSI for a period of 30 days after their surgical procedure. SSI cases were identified according to National Healthcare Safety Network (CDC/NHSN) guideline and Southampton wound scoring system. Univariate and multivariate analysis was