Abstract:
Multisystem inflammatory syndrome in children (MIS-C),
also termed pediatric multisystem inflammatory syndrome (PMIS) temporally associated with coronavirus disease-2019 (COVID-19) is rare but an emerging alarming condition. Though the exact pathogenesis is unknown, COVID-19 can trigger the condition directly or indirectly via immune complex mediated or antibody-dependent enhancement. Patients with MIS-C can present with persistent fever and a constellation of symptoms including hypotension, multiorgan
involvement and elevated inflammatory markers.
Presentations of MIS-C have overlapping features of
Kawasaki disease (KD), toxic shock syndrome (TSS) and
Kawasaki disease shock syndrome. Age of presentation,
features of shock and more predilections for myocardial
dysfunction can distinguish MIS-C from Kawasaki disease.